Program Monday March 24th 2025
Download the book of abstracts here
| 08:45 | Welcome & Coffee in FIRE |
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| 09:30 | Opening by Eelco Ruijter and Iwan de Esch | |
| Keynote I in AIR Chair: Eelco Ruijter |
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| 09:35 | Annamaria Lilienkampf (University of Edinburgh) Antibody-Targeted Bioorthogonal Chemistry |
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| Parallel session I in AIR Chair: Eelco Ruijter |
Parallel session II in WATER Chair: Iwan de Esch |
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| 10:20 | Roy Steneker (UL) Design and synthesis of inhibitors and probes targeting fucose-processing enzymes |
Tom Wennekes (UU) Affinity-based covalent sialyltransferase probes enabled by ligand-directed chemistry |
| 10:35 | Luuk Stringer (UU) Reversible metal-binding with the flick of a light switch |
Qi Wang (RU) Supramolecular Templates as a New Strategy for the Design of Click Reactions |
| 10:50 | Lukas Veth (AMC) [18F]Trifluoromethylation of Thianthrenium Salts via Copper-Mediated Radical-Radical Coupling |
Edith van der Nol (UL) Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation |
| 11:05 | Coffee | |
| Keynote II in AIR Chair: Kevin Neumann |
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| 11:30 | Ilja Voets (Technical University Eindhoven) Some like it cold: from computational protein design to ice-interactive materials for cryopreservation |
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| Parallel session III in AIR Chair: Fedor Miloserdov |
Parallel session IV in WATER Chair: Kevin Neumann |
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| 12:15 | Daan Hoogers (UL) Frontside SN2 Glycosylation Reactions |
Elma Mons (UL) Preclinical Evaluation of Guanidino Lipoglycopeptide Antibiotic EVG7 with Best-in-Class Potential |
| 12:30 | Qianqian Wang (UT) A quantitative approach to assess neuraminidase activity on glycan surfaces |
Dennis Löwik (RU/HAN) Targeted photodynamic therapy for imaging and treatment of cancer |
| 12:45 | Koen Rijpkema (UL) Encounters in Synthesis of ADP-Ribose Analogues |
Tom van der Wel (UL) Genetic and pharmacological inactivation of glycerophosphodiesterase GDE4 promotes oligodendrocyte differentiation and remyelination |
| 13:00 | Lunch in FIRE & SOC ALV (ALV starts at 13:10 in WATER) | |
| KEYNOTE III, Industry talk, KEYNOTE IV in AIR Chair: Bauke Albada |
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| 14:15 | Ilan Marek (Technion, IL) Harnessing Non-Classical Carbocations for Stereoselective Synthesis |
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| 15:00 | Marcel Scheepstra (Synaffix, NL) A Clinical-Stage Platform – Synaffix/Lonza Enabling Best-in-Class Targeted Therapies |
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| 15:30 | Jan van Maarseveen (University of Amsterdam) Not everything was better in earlier days |
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| 16:15 | Posters & Drinks in FIRE | |
| 18:00 | Dinner in the Restaurant | |
| 20:00 | Socializing & Borrel (in FIRE, bar open till midnight) | |
Program Tuesday March 25th 2025
| Keynote V in AIR Chair: Mario van der Stelt |
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| 09:00 | Uwe Grether (Roche, CH) Harnessing Innovation: Chemical Biology, Late Stage Functionalization, and AI in Small Molecule Drug Discovery |
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| Parallel session V in AIR Chair: Fedor Miloserdov |
Parallel session VI in WATER Chair: Mario van der Stelt |
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| 09:45 | Daniël Verdoorn-Kański (UM) Unveiling the Potential of a Cobalt-Based Metal-Organic Framework as a Catalyst in Carbodiimide Synthesis |
Inge Snijders (UL) Photoaffinity-based protein profiling reveals the target of clock-enhancing small molecule 3 |
| 10:00 | Georgia Andriopoulou (UL) Development of Chiral Chemical Libraries for Chemical Proteomics Driven Drug Discovery |
Wanqi Feng (UT) Mucus-mimicking PEG hydrogel for studying the effect of multivalent interactions on virus migration |
| 10:15 | Ahmad Masarwa (HUJI) The Marvel Chemistries of PolyBorylated Alkenes |
Niels Knippenberg (UM) Synthesis of 18F-labeled radioligands for PET imaging of GABA transporter 1 (GAT1) |
| 10:30 | Brecht Ellenbroek (UL) Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC |
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| 10:45 | Coffee / Tea in FIRE | |
| KEYNOTE VI, Industry talk, KEYNOTE VII in AIR Chair: Kim Bonger |
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| 11:15 | Marta Artola (Leiden University) Conformationally Locked Glycosidase Inhibitors, Probes and Degraders: Bridging Chemical Biology and Therapeutic Advances |
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| 12:00 | Bart Herlé (Boehringher Ingelheim) Discovery of Iclepertin |
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| 12:30 | Marc Baggelaar (Utrecht University) Exploring Protein Lipidation by Advanced Chemical Proteomics Strategies |
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| 13:15 | Lunch in FIRE & MCCB ALV (ALV starts at 13:25 in WATER) | |
| Parallel session VII in AIR Chair: Eelco Ruijter |
Parallel session VIII in WATER Chair: Ingrid Dijkgraaf |
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| 14:15 | Femke van der Heijden (UL) Elucidating the Branched ADP-ribose Signaling Pathway |
Mark de Geus (TUD) Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols |
| 14:30 | Minghui Wu (UM) Non-Innocent Behavior of Aromatic Isocyanides under Visible Light: A Pathway to Thioformimidates |
Jan Pascal Kahler (UL) Enhancing Intracellular Activity of Synthetic Transcription Factors via reCHEMbinant Protein Engineering |
| Thesis Winner Talk, KEYNOTE VIII in AIR Chair: Iwan de Esch |
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| 14:45 | Announcement and Lecture winner The Backer-KNCV prize 2025 - Adri Minnaard |
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| 15:15 | John Overington (DrugHunter, UK) Data for drug discovery - how to feed the need for data |
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| 16:00 |
SOC & MCCB Prizes for best oral and poster presentations Closing followed by drinks |
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